I finished my first cycle, 4 days this week. At the end of the 3rd and 4th treatment, so yesterday and today, I felt negligible to no pain.. Yesterday the effect lasted for about a half hour then the pain returned and by maybe 2-3 hours later i was back to the subjective 6 on the pain scale that tends to be my baseline. Tonight the effect lasted for maybe an hour before the perception of the pain returned and now, close to 4 hours later, I'm sitting at about a 4 even despite the fact that the chairs they have for us are hell on my neck and back and head. So that's encouraging. But it is disrupting my sleep pretty severely and that is a side effect in a very small percentage of the population.. So when I resume my next phase next Monday they will give me something extra to try to counteract that part. But if it's still a problem they will cancel the rest of that cycle and just monitor and see if I got enough intervention from what I've had so far. Worked my way up to 175mg today. Not sure what the normal dosing is but that seems somewhat high.