No way. I have a lot of friends in the legal weed business here, and hope to get into it myself. Rubio has stated he would enforce Federal law against states like Colorado (ie unlike most Republicans, him and Christie don't believe in smaller government...at least when it comes to stuff they are morally against). Therefore seeing he doesn't win is in my best interests directly.
At least Bush/Trump/Perry and others have said "I hate the law, but respect the will of the states." Granted they could be lying, but it is what they've promised so they are at least up front saying they'll stay out of it.
Would you blame the coal producer for voting/campaigning against Bernie Sanders, who most likely would use the EPA to shut down more coal mines?