No chance. There is absolutely no doubt that drug/alcohol use is greater in those areas. Unless you believe that sober people behave the same as the intoxicated.
You're kidding, right? Drug/alcohol use is generally constant across the economic spectrum.
https://informahealthcare.com/doi/abs/10.1080/09595230500102434
Whole[sic] poverty and heavy substance use are not necessary related, poverty often increases the harm for a given level of use.
https://link.springer.com/article/10.1007/s10865-007-9098-3
Associations between SES and health behaviors conformed to two patterns. First, low SES was associated with poorer diets, less physical activity, and greater cigarette smoking. Second, there was no clear pattern of associations between SES and alcohol consumption or marijuana use.